My humble opinion is that for low visibility and guns equal or shorter than 110, one short thick band is better because has a lot of punch in short distance and loads faster.
For 120 and longer I'll go with 2 x 16 mm because you will load easier, have less recoil, more power, more reach and can you have the ability to power down.
Right on Marco. Up here in the NE we have limited visibility(8-15ft). Initially I was hunting with (2) 16mm bands but ended up switching to (1) 20mm. It definitely packs more stopping power in a short distance. I like the set-up better personally but I can't speak for 120cm + gun.